Markets brush off Obama win amid gridlock concerns
















LONDON (AP) — The re-election of President Barack Obama gave markets a short-lived boost Wednesday, before concerns over his ability to get a budget agreement from a divided Congress and more grim economic news out of Europe turned sentiment around.


Obama easily clinched a majority in the electoral college, holding on to a raft of key swing states in Tuesday’s vote — despite only just winning the popular vote over his rival Mitt Romney.













Though America has been spared a re-run of the protracted election of 2000, its arms of government remain divided, with the Democrats holding onto their majority in the Senate and the Republicans in control of the House of Representatives. That could still lead to a logjam in policymaking, not least over the parlous state of the country’s public finances, and that’s unsettled investors.


In Europe, stocks gave up their morning gains. The FTSE 100 index of leading British shares was down 0.2 percent at 5,872 while Germany‘s DAX fell 0.4 percent to 7,358. The CAC-40 in France was 0.4 percent lower at 3,465.


Wall Street was poised for a retreat too in contrast to earlier predictions, with both Dow futures and the broader S&P 500 futures down 0.7 percent.


The most pressing matter facing the U.S. government is the so-called “fiscal cliff” — a combination of higher taxes and government spending cuts that automatically take effect unless Congress agrees on a new budget by Jan. 1. Economists warn that a failure to reach a concrete decision will push the world’s largest economy back into recession.


“The initially favorable reaction has evaporated with the ugly task of dealing with the fiscal cliff eclipsing earlier optimism,” said Andrew Wilkinson, chief economic strategist at Miller Tabak & Co.


Sentiment has also been hit by a downbeat set of European economic forecasts from the European Commission. The executive arm of the European Union now expects the 17-country eurozone to contract by 0.4 percent this year and to grow by only 0.1 percent next.


The turnaround in stocks markets was evident in currencies too— when risk appetite wanes, the dollar usually finds support. By early afternoon London time, the euro was 0.4 percent lower at $ 1.2754, a full cent lower than where it had been trading earlier.


Investors are also turning their gaze towards a crucial vote in the Greek Parliament later. If lawmakers don’t back a €13.5 billion ($ 17.3 billion) package of spending cuts and tax increases, the country faces the prospect of losing access to its bailout lifeline and potentially defaulting on its mountain of debt and leaving the euro.


That toxic combination could have massive negative repercussions in financial markets, regardless of whether a bipartisan budget solution is reached in the U.S. in the coming weeks.


“Strange to think that over 100 million votes cast in the U.S. may have less impact upon the markets over the next month or so than some 300 votes due to be cast in the Greek parliament this evening,” said Gary Jenkins, managing director of Swordfish Research.


Earlier in Asia, Japan‘s Nikkei 225 index closed marginally lower at 8,972.89. Hong Kong‘s Hang Seng added 0.7 percent to 22,099.85. South Korea‘s Kospi gained 0.5 percent to 1,937.55.


Mainland Chinese shares edged lower, with Shanghai Composite Index slipping marginally to 2,105.73. The smaller Shenzhen Composite Index lost 0.2 percent to 851.64


Also on investors’ radar is Thursday’s opening of China‘s Communist Party congress — the once-in-a-decade forum to name China’s top leadership. Although current Vice President Xi Jinping is almost certain to be China’s next leader, markets will be looking for hints on how the new leadership plans to tackle the nation’s economic slowdown.


In the oil markets, a price of benchmark New York crude was down $ 1.21 to $ 87.51 per barrel in electronic trading on the New York Mercantile Exchange.


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Canada firms to capitalize on nuclear trade with India
















NEW DELHI (Reuters) – Canadian firms will be able to export uranium and nuclear reactors to India for the first time in almost four decades under an agreement between the two nations, their prime ministers said, but more work is needed to implement the deal.


Once implemented, the agreement will end a ban on nuclear cooperation Canada imposed in 1976 after India secretly exploded its first nuclear bomb in 1974, commonly called the “Smiling Buddha”, using material from a Canadian-built reactor in India.













“Being able to resolve these issues and move forward is, we believe, a really important economic opportunity for an important Canadian industry, part of the energy industry, that should pay dividends in terms of jobs and growth for Canadians down the road,” Canadian Prime Minister Stephen Harper said on Tuesday on a visit to New Delhi.


A negotiator with the Canadian Nuclear Safety Commission (CNSC), speaking on condition of anonymity because of the delicacy of the talks, said that what remained was a careful legal review of the language; translation into French and Hindi; and then a signing.


This is not expected to take very long, he said. The two sides have set up a joint committee to liaise on nuclear issues, but he said it would not be negotiating.


India aims to lift its nuclear capacity to 63,000 MW in the next 20 years by adding nearly 30 reactors. The country currently operates 20 mostly small reactors at six sites with a capacity of 4,780 MW, or 2 percent of its total power capacity, according to the Nuclear Power Corporation of India Limited.


Canada’s ambassador to India, Stewart Beck, said on Monday his country wanted to be able to track all nuclear material, but that India felt it only needed to report to the International Atomic Energy Agency (IAEA).


It was not clear who made concessions in the talks and how effective the safeguards would be to ensure that Canadian material did not get used again for making nuclear weapons.


However, the CNSC official said India would now be required to notify Canada of any transfers to a third country and trade could only go to facilities that are safeguarded by the IAEA.


PROBABLY BEATING AUSTRALIA


Harper said the CNSC had worked to “achieve all of our objectives in terms of non-proliferation”.


Canada is in a race against Australia, its strategic ally but a commercial rival in the uranium business. Australia is also trying to nail down safeguards under which it too could sell uranium to India.


“We are effectively ahead of the Australians,” the CNSC official said, noting however that Russia and Kazakhstan were already supplying into India.


Opening up the Indian market would be a big help to Canada’s Cameco Corp, which is the world’s largest publicly traded uranium producer but which recently cut its long-term output targets due to the Fukushima disaster.


“Anytime we can reduce the roadblocks to selling our product around the world is always helpful,” Cameco chief executive Tim Gitzel told Reuters in Canada. “It opens a new market for us with the appropriate safeguards in place. So this is good news.”


Another potential beneficiary is Canadian engineering firm SNC Lavalin Group Inc, which bought the government’s commercial nuclear division, which designed the Candu reactor that is in use in numerous countries.


“As far as the sales of reactors goes, we would normally now request that Canada be accorded the same treatment as the Russians, the French and the Americans and that a site be designated in India for the implementation of at least a twin- unit Candu nuclear power station,” SNC Lavalin International President Ronald Denom, part of Harper’s delegation in India, told Reuters.


He also said it should open up the market to service the existing reactors in India.


Harper also said Canada welcomed foreign investment, after the country temporarily blocked Malaysian state oil firm Petronas’ C$ 5.17 billion ($ 5.19 billion) bid for gas producer Progress Energy Resources on October 20.


Late on Friday, Canada extended to December 10 its review of a $ 15.1 billion bid made in July by China’s CNOOC Ltd for Canadian energy producer Nexen Inc.


“Those decisions have to be taken looking at the global evolving economy in which we operate,” Harper said.


($ 1 = C$ 0.9965)


(Additional reporting by Julie Gordon in Toronto; Additional writing by Frank Jack Daniel; Editing by Jonathan Thatcher and Michael Roddy)


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American composer Elliott Carter dies at age 103
















(Reuters) – Classical composer Elliott Carter, who twice won Pulitzer Prizes in a career that spanned more than 75 years, died on Monday in New York at age 103, music publisher Boosey & Hawkes said.


Carter was awarded Pulitzer Prizes in 1960 and 1973 for string quartet compositions. He composed 158 works, including several at over 100 years of age. One composition for chamber orchestra is scheduled for a world premier in February.













“The great range and diversity of his music has, and will continue to have, influence on countless composers and performers worldwide,” the publisher said. “He will be missed by us all but remembered for his brilliance, his wit and his great canon of work.”


He was inducted into the American Classical Music Hall of Fame in 1998 and celebrated his 100th birthday at New York‘s Carnegie Hall in 2008 with a new work performed by the Boston Symphony Orchestra.


Carter was presented the National Medal of Arts, the highest award given to artists by the United States, in 1985. He also received national honors from Germany and France.


(Reporting by David Bailey; Editing by Cynthia Johnston and Mohammad Zargham)


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St Jude device lowers blood pressure in small study
















(Reuters) – St Jude Medical Inc said on Monday its procedure that deadens nerves near the kidneys helped lower blood pressure in a small study of patients whose hypertension could not be controlled with drugs.


Patients in the study who were treated with the Enlightn renal denervation system saw an average reduction of 28 points in systolic blood pressure, which is the first number expressed in a reading, after 30 days. At six months, the 46 patients who received the treatment maintained an average systolic blood pressure reduction of 26 mmHg points.













The results were presented at the annual meeting of the American Heart Association in Los Angeles.


Patients enrolled in the study had an average blood pressure of 176/96 mmHg despite being treated with multiple medications to manage the condition. No serious side effects were reported, St Jude said.


Normal blood pressure is below 120/80 mmHg. Hypertension, or high blood pressure, is a reading above 140/90 mmHg.


Renal denervation is a procedure in which a thin, flexible catheter is threaded through the body to the renal sympathetic nerves near the kidneys. Radiofrequency energy is delivered to disrupt the nerve activity, relieving high blood pressure.


Millions of people have hypertension that is resistant to drugs, putting them at risk of heart attacks and stroke.


The new therapy is not yet approved in the United States, but several products are already available in Europe.


Device makers that have already received approval to sell hypertension devices in Europe include Medtronic, the front-runner, St Jude, Covidien, ReCor Medical and Vessix Vascular.


St Jude shares were up 29 cents, or less than 1 percent, at $ 38.80 in afternoon trading on the New York Stock Exchange.


(Reporting By Susan Kelly and Debra Sherman in Chicago; Editing by Gerald E. McCormick, Leslie Adler and Jim Marshall)


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Ahead of the Bell: Express Scripts plummets
















NEW YORK (AP) — Shares of Express Scripts slid in premarket trading Tuesday after the pharmacy benefits manager warned that persistent high joblessness and economic uncertainty would make 2013 more challenging, and expectations of Wall Street analysts were too high.


Pharmacy benefits managers, or PBMs, run prescription drug plans for employers, insurers and other customers. They process mail-order prescriptions and handle bills for prescriptions filled at retail pharmacies.













The St. Louis company handles more than a billion prescriptions each year after the $ 29.1 billion acquisition of a rival, Medco, in April.


Analysts were disappointed by the company’s outlook. Investors will now question whether Express Scripts benefits as much from recent acquisitions as the company had led them to believe, said Citi analyst George Hill, calling the company’s forecast “baffling.”


Express Scripts had lifted its 2012 earnings forecast in August after recording better-than-expected savings from its combination with Medco.


Jefferies analyst Brian Tanquilut lowered his rating on Express Scripts to “Hold” from “Buy” and cut his price target on the shares by $ 14 to $ 56.


Shares of Express Scripts Holding Co. dropped $ 8.25, or 13 percent, to $ 54.63 before the opening bell. The stock was up 41 percent so far this year through Monday’s trading.


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Cautious reformers tipped for new China leadership
















BEIJING (Reuters) – China‘s ruling Communist Party will this month unveil its new top leadership team, expected to again be an all-male cast of politicians whose instincts are to move cautiously on reform.


Sources close to the leadership say 10 main candidates are vying for seven seats on the party’s next Politburo Standing Committee, the peak decision-making body which will steer the world’s second-largest economy for the next five years.













Only two candidates are considered certainties going into the party’s 18th congress, which starts on Thursday: leader-in-waiting Xi Jinping and his designated deputy, Li Keqiang, who are set to be installed as president and premier next March.


Of the remaining eight contenders, only one has the reputation as a political reformer and only one is a woman.


Following are short biographies of the candidates, including their reform credentials and possible portfolio responsibilities.


XI JINPING


REFORM CREDENTIALS: Considered a cautious reformer, having spent time in top positions in Fujian and Zhejiang provinces, both at the forefront of China‘s economic reforms.


Xi Jinping, 59, is China‘s vice president and President Hu Jintao’s anointed successor. He will take over as Communist Party boss at the congress and then as head of state in March.


Xi belongs to the party’s “princeling” generation, the offspring of communist revolutionaries. His father, former vice premier Xi Zhongxun, fought alongside Mao Zedong in the Chinese civil war. Xi watched his father purged and later, during the Cultural Revolution, spent years in the hardscrabble countryside before making his way to university and then to power.


Married to a famous singer, Xi has crafted a low-key and sometimes blunt political style. He has complained that officials’ speeches and writings are clogged with party jargon and has demanded more plain speaking.


Xi went to work in the poor northwest Chinese countryside as a “sent-down youth” during the chaos of the 1966-76 Cultural Revolution, and became a rural commune official. He went on to study chemical engineering at Tsinghua University in Beijing and later gained a doctorate in Marxist theory from Tsinghua.


A native of the poor, inland province of Shaanxi, Xi was promoted to governor of southeastern Fujian province in 1999 and became party boss in neighboring Zhejiang province in 2003.


In 2007, the tall, portly Xi secured the top job in China‘s commercial capital, Shanghai, when his predecessor was caught up in a huge corruption case. Later that year he was promoted to the party’s standing committee.


- – - -


LI KEQIANG


REFORM CREDENTIALS: Seen as another cautious reformer due to his relatively liberal university experiences.


Vice Premier Li Keqiang, 57, is the man tipped to be China‘s next premier, taking over from Wen Jiabao.


His ascent will mark an extraordinary rise for a man who as a youth was sent to toil in the countryside during Mao’s Cultural Revolution.


He was born in Anhui province in 1955, son of a local rural official. Li worked on a commune that was one of the first places to quietly revive private bonuses in farming in the late 1970s. By the time he left Anhui, Li was a Communist Party member and secretary of his production brigade.


He studied law at the elite Peking University, which was among the first Chinese schools to resume teaching law after the Cultural Revolution. He worked to master English and co-translated “The Due Process of Law” by Lord Denning, the famed English jurist.


In 1980, Li, then in the official student union, endorsed controversial campus elections. Party conservatives were aghast, but Li, already a prudent political player, stayed out of the controversial vote.


He climbed the party ranks and in 1983 joined the Communist Youth League’s central secretariat, headed then by Hu Jintao.


Li later served in challenging party chief posts in Liaoning, a frigid northeastern rustbelt province, and rural Henan province. He was named to the powerful nine-member standing committee in 2007.


- – - -


WANG QISHAN


REFORM CREDENTIALS: A financial reformer and problem solver with deep experience tackling tricky economic and political problems.


Wang Qishan, 64, is the most junior of four vice premiers and an ex-mayor of Beijing. But he has a keen grasp of complex economic issues and is the only likely member of the Standing Committee to have been chief executive of a corporation, leading the state-owned China Construction Bank from 1994 to 1997. As such, he may take a leading role in shaping economic policy, including trade and foreign investment.


Wang is an experienced negotiator who has led finance and trade negotiations as well as the Strategic and Economic Dialogue with the United States. He is a favorite of foreign investors and has long been seen as a problem solver, sorting out a debt crisis in Guangdong province where he was vice governor in the late 1990s and replacing the sacked Beijing mayor after a cover-up of the deadly SARS virus in 2003.


Wang is also a princeling, son-in-law of a former vice premier and ex-standing committee member, Yao Yilin. His possible portfolio could be chairman of the National People’s Congress (China’s rubber-stamp parliament), head of parliament’s advisory body, executive vice premier (responsible for economic issues) or the party’s top anti-corruption official.


- – - -


LIU YUNSHAN


REFORM CREDENTIALS: A conservative who has kept domestic media on a tight leash.


Liu Yunshan, 65, may take over the propaganda and ideology portfolio for the Standing Committee.


He has a background in media, once working as a reporter for state-run news agency Xinhua in Inner Mongolia, where he later served in party and propaganda roles before shifting to Beijing.


As minister of the party’s Propaganda Department since 2002, Liu has also sought to control China‘s Internet, which has more than 500 million users. He has been a member of the wider Politburo for two five-year terms ending this year.


Liu has not worked directly for the Communist Youth League, but is aligned to it through his lengthy career in an inland, poor province, long ties to the party’s propaganda system and close relationship with Hu Jintao.


- – - -


LI YUANCHAO


REFORM CREDENTIALS: A reformer who has courted foreign investment and studied in the United States.


Li Yuanchao, 61, oversees the appointment of senior party, government, military and state-owned enterprise officials as head of the party’s powerful organization department. On the Standing Committee, he could head the fight against corruption.


Li, whose father was a vice-mayor of Shanghai, has risen far since his parents were persecuted and he was a humble farm hand during the Cultural Revolution.


Politically astute, Li can navigate between interest groups, from Hu’s Youth League power base to the princelings.


As party chief in his native province, Jiangsu, from 2002 to 2007, Li oversaw a rapid rise in personal incomes and economic development, attracting foreign investment from global industrial leaders such as Ford, Samsung and Caterpillar.


He earned mathematics and economics degrees from two of China‘s best universities and a doctorate in law. He also spent time at Harvard University’s Kennedy School of Government in the United States.


- – - -


ZHANG DEJIANG


REFORM CREDENTIALS: A conservative trained in North Korea.


Zhang Dejiang, 65, saw his chances of promotion boosted this year when he was chosen to replace disgraced politician Bo Xilai as Chongqing party boss. He also serves as vice premier in charge of industry, though his record has been tarnished by the downfall of the railway minister last year for corruption.


Zhang is close to former president Jiang Zemin who still wields some influence. He studied economics at Kim Il-sung University in North Korea and is a native of northeast China.


On his watch as party chief of Guangdong, the southern province maintained its position as a powerhouse of China‘s economic growth, even as it struggled with energy shortages, corruption-fuelled unrest and the 2003 SARS epidemic.


- – - – -


ZHANG GAOLI


REFORM CREDENTIALS: A financial reformer with experience in more developed parts of China.


Zhang Gaoli, 65, party chief of the northern port city of Tianjin and a Politburo member since 2007, is seen as a Jiang Zemin ally but also acceptable to President Hu, who has visited Tianjin three times since 2008. Zhang is an advocate of greater foreign investment and he introduced financial reforms in a bid to turn the city into a financial center in northern China.


He was sent to clean up Tianjin, which was hit by a string of corruption scandals implicating his predecessor and the former top adviser to the city’s lawmaking body. The adviser committed suicide shortly after Zhang’s arrival.


A native of southeastern Fujian province, Zhang trained as an economist. He also served as party chief and governor of eastern Shandong province and as Guangdong vice governor.


Zhang is low-key with a down-to-earth work style, and not much is known about his specific interests and aspirations. But with his leadership experience in more economically advanced cities and provinces, including party secretary of the showcase manufacturing and export-driven city of Shenzhen, he could be named executive vice premier.


- – - – -


WANG YANG


REFORM CREDENTIALS: Seen by many in the West as a beacon of political reform.


Wang Yang, 57, is party chief of the export dependent economic hub of Guangdong province. He was not included in a list of preferred Standing Committee candidates drawn up by Xi, Hu and Hu’s predecessor, Jiang Zemin, according to sources close to the leadership, but is firmly in the running.


Born into a poor rural family in eastern Anhui province, Wang dropped out of high school and went to work in a food factory at age 17 to help support his family after his father died. These experiences may have shaped his desire for more socially inclusive policies, including his “Happy Guangdong” model of development designed to improve quality of life.


Concerned about the social impact of three decades of blistering development, he lobbied for social and political reform. However, this approach has drawn criticism from party conservatives and Wang has more recently adopted the party’s more familiar method of control and punishment to keep order.


- – - – -


YU ZHENGSHENG


REFORM CREDENTIALS: Relatively low-key but considered a cautious reformer.


Yu Zhengsheng, 67, is party boss in China‘s financial hub and most cosmopolitan city, Shanghai.


His impeccable Communist pedigree made him a rising star in the mid-1980s until his brother, an intelligence official, defected to the United States. His close ties with Deng Pufang, the eldest son of late paramount leader Deng Xiaoping, spared him the full political repercussions but he was taken off the fast track.


Yu bided his time in ministerial ranks until bouncing back, joining the Politburo in 2002. However, the princeling’s age would require him to retire in 2017 after one term.


- – - – -


LIU YANDONG


REFORM CREDENTIALS: Uncertain.


Liu Yandong, who turns 67 this month, is the only woman given a serious chance to join the Standing Committee but is considered a dark horse. She is a princeling also tied to President Hu’s Youth League faction.


If promoted, she could head up parliament’s advisory body, but her age would also force her to retire after only one term.


Her bigger challenge is that no woman has made it into the Standing Committee since 1949. Not even Jiang Qing, the widow of late Chairman Mao Zedong, made it that far.


Liu, daughter of a former vice-minister of agriculture, is currently the only woman in the 25-member Politburo, a minority in China‘s male-dominated political culture. She has been on the wider Politburo since 2007 as one of five state councilors, a rank senior to a cabinet minister but junior to a vice-premier.


(Reporting by Terril Yue Jones, Ben Blanchard, Benjamin Kang Lim and Sui-Lee Wee in Beijing. Additional reporting by Chris Ip, Grace Li, Jean Lin, Young Wang, Alice Woodhouse and Julie Zhu; Editing by Raju Gopalakrishnan and Mark Bendeich)


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The app’s the thing as Shakespeare goes digital
















TORONTO (Reuters) – William Shakespeare‘s plays are getting a 21st century-style makeover in the form of new apps for tablets and smart phones nearly 500 years after the Bard took pen to parchment.


Plays such as “Romeo and Juliet” and “Macbeth” spring to life in iPad apps released by Cambridge University Press, which pairs the texts with audio performances, commentary and other interactive content, transforming the classic plays for the digital age.













The apps are part of a new series called Explore Shakespeare that was introduced by the British publishing house to expand the playwright’s reach to casual readers.


“A lot of people have a copy of Shakespeare on their bookshelf that they never got around to reading because they have this idea that Shakespeare is hard or has to be studied to be appreciated,” said John Pettigrew, executive producer of the Explore Shakespeare series.


Pettigrew believes the plays are meant to be enjoyed and are accessible provided readers are given context to overcome outdated or poetic language.


While the core focus of the app is on the actual text, readers can consult glossaries, notes, photos and synopses at any point in the script.


“Everything there is designed to keep you in the play and to put you in the mind of the actor, director or writer,” he explained.


To understand less common language, readers can tap on words and phrases to delve into their meaning.


“A classic one is in ‘Romeo and Juliet‘ which is `wherefore art thou Romeo?’ It’s not ‘where are you Romeo?’, It’s `why are you Romeo?` So that kind of phrase gets a glossary to explain what is meant,” said Pettigrew.


The apps also include full audio performances from stars such as Kate Beckinsale and Martin Sheen. Other features help readers to visualize relations between actors in a scene, understand how Shakespeare interweaves themes throughout the play, and to analyze the text more thoroughly.


“You can delve into the language or themes or interpretation, but our first task is to show that it’s just a good story,” Pettigrew said.


Although the app was designed with consumers in mind, Pettigrew believes it could also play a role in education, with students embracing the app over its print counterpart.


“For a 13-year old, Shakespearean language can be a barrier and to have something right there on the page is really helpful,” he said.


According to Pettigrew, the publishing house chose to develop it for the iPad because it is the dominant tablet platform in schools, but he said they are considering Android and Windows 8 apps in the future.


Four more apps including “Twelfth Night,” “A Midsummer’s Night Dream,” “Hamlet” and “Othello” are due to be released in coming months. They are available worldwide for $ 13.99 each.


Pettigrew said the app is vetted for accuracy by experts and includes ancillary material, which is designed to augment the original text.


“To borrow a Shakespeare phrase, ‘the play’s the thing.’”


(Editing by Patricia Reaney and David Gregorio)


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Sharon Osbourne has double mastectomy
















LONDON (AP) — Sharon Osbourne says she had a double mastectomy after learning she carries a gene that increases the risk of developing breast cancer.


Osbourne told Hello! magazine that “I didn’t want to live the rest of my life with that shadow hanging over me.”













The 60-year-old “America’s Got Talent” judge, who had colon cancer a decade ago, said that without the surgery, “the odds are not in my favor.”


She added: “It’s not ‘pity me,’ it’s a decision I made that’s got rid of this weight that I was carrying around.”


The magazine went on sale Monday.


Osbourne, husband Ozzy and children Jack and Kelly became rock’s most famous clan thanks to reality show “The Osbournes” a decade ago.


Jack Osbourne, 26, was recently diagnosed with multiple sclerosis.


Entertainment News Headlines – Yahoo! News



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Dog Tumors May Give Clues for Human Breast Cancer
















Luke Robinson never liked dogs much until an ex-girlfriend offered him a puppy while he was living in San Antonio, Texas. The Great Pyrenees he named Malcolm changed all that.


“It was the first dog of my adult life,” said Robinson, 41. “He was my companion, my mate.”













But at the age of 6, Malcolm was diagnosed with bone cancer — which both devastated and mobilized Robinson.


When a veterinarian from a major university couldn’t tell Robinson why Malcolm got cancer at such young age, he went on a national crusade to “find out why.”


Robinson walked 2,300 miles over two years to raise awareness, founding in the process Two Million Dogs, an organization that is a pioneer in the field of comparative research — finding common links between animals and humans who have cancer.


Today, a $ 50,000 grant from the organization is funding such research at Princeton University to learn how breast cancer tumors progress from seemingly benign to malignant ones.


“We are using new model — no one looked at progression this way,” said Olga Troyanskaya, the computational biologist who is leading the genetic research. “It’s something that is really out there and forward-thinking.”


Troyanskaya is collaborating with Karen Sorenmo, an oncologist at the Ryan Veterinary Hospital at the University of Pennsylvania, who has a special interest in mammary tumors.


The pair met when Troyanskaya‘s German shepherd Jessie was diagnosed with terminal cancer in 2006, and she sought help from Sorenmo.


Sorenmo provided the Princeton project with tumors from shelter dogs that get free treatment from shelter dogs.


Dogs have multiple mammary glands and when they develop cancer, unlike humans, they can have multiple tumors.


“The screening is not as good, but when found, on average they have seven masses at different stages of development,” said Troyanskaya. “Some are benign … but they are not truly benign.”


Troyanskaya compares dog and human tumors on a molecular level and hopes to find genetic markers that can give clues to how human breast cancer tumors progress and which ones are more likely to become malignant.


“We are looking at progression in a unique model,” she said. “Way more research has been done in mice … Dogs get these tumors naturally and the physiology is more similar, the way tumors rise is similar, with the hormonal link to breast cancer in women.”


Troyanskaya said she hopes to find targets for drug treatment or predict clinical outcomes in women with breast cancer and help speed up human trials.


“We can help dogs and humans,” she said.


Robinson has been the visionary in this comparative research. His own journey began in 2006 when his dog Malcolm’s cancer had spread to his lungs. Even medical experts at Tufts University could not explain to Robinson why such a young dog would be so sick.


“I took great care of him and learned everything about caring for a dog,” he said. “I did everything I was told to do.”


Malcolm died, but two years later, in 2008, the questions still gnawed at Robinson. So he dropped out of the world of finance, put all his belongings in storage and set out to walk across 16 states with two new healthy dogs, Hudson and Murphy.


“My goal was to share Malcolm’s story,” he said. And along the way, he consulted with veterinary experts to know why his dog died.


“I didn’t have a choice,” said Robinson. “He was my boy and he changed my life fundamentally. Some people continue on the same course. For me, it was life-defining.”


In 2010, he set up Two Million Dogs, believing that dogs, who live in the same environment as humans, can give clues to why humans get cancer.


“They are like the canary in the coal mines — we drink the same water,” said Robinson.


Today, Robinson is still homeless and jobless, but a tireless advocate for comparative research.


The organization he founded for sponsors is called “Puppy-Up Walks” — similar to the fundraising efforts for the Susan G. Komen for the Cure foundation and hosted in in 40 cities around the country.


Sadly, Robinson’s Great Pyrenees, Murphy, died of nasal cancer in June. And now, the man who never thought he would fall in love with a dog has a new puppy, Indiana.


“Before,” he said of Malcolm, “I didn’t know I could have a spiritual connection with an animal.”


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